Therapeutic Asset Ratings

Neukoplast™

Obecabtagene Autoleucel

Pbsc

Ptg-Carcik-Cd19

Rabbit Anti-Human Thymocyte Globulin

RETINOL

Sc-Peg

shr2554

Tirzepatide

UREA, N-(2-CHLOROETHYL)-N'-(4-METHYLCYCLOHEXYL)-N-NITROSO-

Navitoclax

Itacitinib

Orca-Q

Recombinant Human Granulocyte Colony-Stimulating Factor

Lapine T-Lymphocyte Immune Globulin

Dilanubicel

Rimiducid

cta101

Tozinameran

Asciminib

Autologous Hucd19 Car T Cells

Autologous T cells obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, nonreplicating lentiviral vector, encoding a T cell chimeric antigen receptor targeting CD19. The expressed transgene comprises a CD8? leader sequence, a murine anti-CD19 single chain variable fragment (scFv) derived from the mouse hybridoma FMC63, a CD8? hinge and transmembrane region, and a 4-1BB (CD137) and CD3? (TCR?) signaling domain and is under control of the elongation factor 1 alpha (EF1?) promoter. The construct is flanked by 5' and 3' long terminal repeats (LTRs) and also contains a ? packaging signal, a Rev response element (RRE), a central polypurine tract (cPPT) sequence and an optimized Woodchuck hepatitis virus posttranscriptional regulatory element (WPRE). The leukapheresis material is enriched for CD4/CD8 T cells by positive immunoselection, activated by CD3 and CD28 agonists and transduced with the vector. Without further cell propagation, the T cells are washed, formulated for infusion, and cryopreserved. The substance is composed of ?80% T cells and ?1% B cells, with a mixture of transgene positive (>3.4%) and negative T cells. The CD4+ and CD8+ naïve T cell subsets (CD45RA+CCR7+) present in the leukapheresis material are largely retained

Capivasertib

cd19-car_lenti t cell

cd19/cd22-car-transduced t cells