allogeneic natural killer (NK) cells isolated from peripheral blood leukapheresis of individual donors. The cells are co-cultured in media containing interleukin 15 (IL-15) and nicotinamide (NAM, niacinamide) with expansion enhanced by the presence of feeder cells. The final cell population consists of 97-99% CD3-CD56+ NK cells, with >10% expressing CD16 (also known as Fc?RIII) and CD62L (also known as L-selectin) and with capacity to degranulate (surface expression of CD107? [Lysosome-associated membrane glycoprotein 1]; >10%), and to kill target cells (>10%) in co-culture assays against human cancer cell lines.
Recurrent Glioblastoma
Rating breakdown
- Clinical Evidence
- 28/ 100
- Competitive Position
- 81/ 100
Competitive context
353 Active assets in the Recurrent Glioblastoma cohort.
| Asset / Sponsor | Phase | Rating |
|---|---|---|
Irinotecan Beijing Sanbo Brain Hospital | Phase 2/3 | BBB |
Depatuxizumab Mafodotin AbbVie | Phase 3 | BB |
CARMUSTINE Leland Metheny | Phase 3 | BB |
Irinotecan University of Cincinnati | Phase 3 | BB |
(+)-VINCRISTINE University of Cincinnati | Phase 3 | BB |
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Same molecule, other indications
allogeneic natural killer (NK) cells isolated from peripheral blood leukapheresis of individual donors. The cells are co-cultured in media containing interleukin 15 (IL-15) and nicotinamide (NAM, niacinamide) with expansion enhanced by the presence of feeder cells. The final cell population consists of 97-99% CD3-CD56+ NK cells, with >10% expressing CD16 (also known as Fc?RIII) and CD62L (also known as L-selectin) and with capacity to degranulate (surface expression of CD107? [Lysosome-associated membrane glycoprotein 1]; >10%), and to kill target cells (>10%) in co-culture assays against human cancer cell lines. is also rated in:
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