Floatz Rating
BB70/100
Confidence
Indicative
Sponsor
Madigan Army Medical Center
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
57High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT00862095CT.gov Medical Therapies for Chronic Post-Traumatic Headaches | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Headache Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Apsolol (this asset) | Madigan Army Medical Center | Approved | BB · 70 |
| Topiramate | University of Minnesota | P4 | BBB |
| Dfn-11 (Sumatriptan Injection) | Danish Headache Center | P4 | BBB |
| Lidocaine | Daniel A Tonetti, MD | P4 | BBB |
| Prochlorperazine | Wake Forest University Health Sciences | P4 | BBB |
| Propofol | Medical College of Wisconsin | P4 | BBB |
| Marcaine | HCA Florida North Florida Hospital | P4 | BBB |
| Naproxen | Ache Laboratorios Farmaceuticos S.A. | P4 | BBB |
| Amitriptyline | Children's Hospital Medical Center, Cincinnati | P4 | BB |
+42 more in the Headache Disorder cohort
Other indications for Apsolol
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Esophageal Varices | — | P4 | BBB · 74 |
| Migraine Disorder | — | P4 | BBB · 74 |
| Esophageal Varices With Bleeding | — | P4 | BBB · 73 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Apsolol in Headache Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/apsolol-headache-disorder
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