Cytarabine
High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit
Explore 34 assets in High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit →Floatz Rating
CCC50/100
Confidence
Indicative
Sponsor
Yazeed Sawalha
Modality
Small molecule
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
40Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06536049CT.gov Epcoritamab Plus Ibrutinib for the Treatment of Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphoma | — | Recruiting | — | — | — |
NCT05228249CT.gov Loncastuximab Tesirine in Combination With Chemotherapy Prior to Stem Cell Transplant for the Treatment of Recurrent or Refractory Diffuse Large B-Cell Lymphoma | — | Withdrawn | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Cytarabine (this asset) | Yazeed Sawalha | P1/2 | CCC · 50 |
| Rituximab | Yazeed Sawalha | P2 | B |
| Cyclophosphamide | Mayo Clinic | P2 | B |
| Etoposide | David Bond, MD | P2 | B |
| Dexasone | National Cancer Institute (NCI) | P2 | B |
| Ibrutinib | National Cancer Institute (NCI) | P2 | B |
| (+)-Vincristine | Patrick C. Johnson, MD | P2 | B |
| Prednisone | National Cancer Institute (NCI) | P2 | B |
| Venetoclax | National Cancer Institute (NCI) | P2 | B |
+32 more in the High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit cohort
Other indications for Cytarabine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Acute Promyelocytic Leukemia | — | P4 | A · 82 |
| Adult Acute Lymphoblastic Leukemia | — | P4 | BBB · 79 |
| Acute Myeloblastic Leukemia With Maturation | — | P3 | BBB · 78 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Cytarabine in High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/cytarabine-high-grade-b-cell-lymphoma-double-hittriple-hit
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