Floatz Rating
CC41/100
Confidence
Indicative
Sponsor
Duke University
Modality
monoclonal_antibody
Development Phase
Early Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04937413CT.gov The PCSK9i Inhibitor Evolocumab - a Surgical Trial of Pharamcodynamics and Kinetics Evaluation | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Malignant Glioma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Evolocumab (this asset) | Duke University | Early P1 | CC · 41 |
| Irinotecan | Kailin Yang, MD, PhD | P2 | BB |
| Marizomib | Aadi Bioscience, Inc. | P2 | BB |
| Valaciclovir | Trogenix ltd | P2 | BB |
| Disodium 4-((Tert-Butylimino)Methyl)Benzene-1,3-Disulfonate N-Oxide | Oblato, Inc. | P2 | BB |
| Lenalidomide | M.D. Anderson Cancer Center | P2 | B |
| Nogitecan | Jeffrey N. Bruce | P2 | B |
| Gm-Csf | Gary Archer Ph.D. | P2 | B |
| Chlorotoxin | TransMolecular | P2 | B |
+42 more in the Malignant Glioma cohort
Other indications for Evolocumab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Cardiovascular Disorder | — | P4 | B · 63 |
| Myocardial Infarction | — | P4 | B · 63 |
| Coronary Artery Disorder | — | P3 | B · 62 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Evolocumab in Malignant Glioma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/evolocumab-malignant-glioma
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