gamma1 heavy chain humanized (1-453) [VH (Homo sapiens IGHV1-3*01 (80.4%)--(IGHD) -IGHJ3*01 (92.3%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1, CH1 K120, CH3 E12, M14, G1v14 CH2 1.3, A1.2 (CH1 R120>K (220) (124-221) hinge 1-15 (222-236), CH2 L1.3>A (240), L1.2>A (241) (237-346), CH3 E12 (362), M14 (364) (347-451), CHS (452-453))(124-453)], (226-213')-disulfide with kappa light chain humanized (1'-213') [V-KAPPA (Homo sapiens IGKV3-11*01 (82.1%) -IGKJ2*02 (100%), CDR-IMGT [5.3.9] (27-31.49-51.88-96)) (1'-106') -Homo sapiens IGKC*01 (100%), Km3, A45.1 (152), V101 (190) (107'-213')], dimer (232-232'':235-235'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1 lacking the glutamine synthetase (GS-KO) gene, glycoform alfa
Advanced Solid Tumor
Elpiscience Biopharma, Ltd.monoclonal_antibodyPhase 1Active
C
39/ 100
Provisional rating · Methodology v0.2
Rating breakdown
- Clinical Evidence
- 32/ 100
- Competitive Position
- 59/ 100
Competitive context
1411 Active assets in the Advanced Solid Tumor cohort.
| Asset / Sponsor | Phase | Rating |
|---|---|---|
Nabiximols Jazz Pharmaceuticals | Phase 3 | BBB |
Vitamin B6 M.D. Anderson Cancer Center | Phase 4 | BB |
Inno-206 M.D. Anderson Cancer Center | Phase 2 | BB |
PROPOFOL Hong Kong Children's Hospital | Phase 4 | BB |
Desflurane Peter MacCallum Cancer Centre, Australia | Phase 4 | BB |
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