Discovery Hub
H-gamma1 heavy chain anti-ERBB2 fused to a scFvlh anti-TNFRSF9 (1-719) [H-gamma1 heavy chain anti-ERBB2 humanized (1-450) [VH (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120)-Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)] -18-mer enneakis (glycylseryl) linker (451-468) -scFvlh anti-TNFRSF9 Homo sapiens (469-719), 11-scFv-v2 C120 (VL)-C49 (VH) [V-LAMBDA (Homo sapiens IGLV1-47*02 (91.8%) -IGLJ2*01 (90.9%) VL G120>C (571), CDR-IMGT [8.3.11] (493-501.519-521.558-568)) (469-578) -20-mer tetrakis(tetraglycyl-seryl) linker (579-598) -VH (Homo sapiens IGHV3-23*01 (93.9%) -IGHD -IGHJ4*01 (100%) VH G49>C (642), CDR-IMGT [8.8.14] (624-631.649-656.695-708)) (599-719)]]; (223-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-39*01 (86.3%) -IGKJ1*01 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

H-gamma1 heavy chain anti-ERBB2 fused to a scFvlh anti-TNFRSF9 (1-719) [H-gamma1 heavy chain anti-ERBB2 humanized (1-450) [VH (Homo sapiens IGHV3-6601 (81.6%) -(IGHD) -IGHJ401 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120)-Homo sapiens IGHG103v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (217) (121-218), hinge 1-15 (219-233), CH2 (234-343), CH3 E12 (359), M14 (361) (344-448), CHS (449-450)) (121-450)] -18-mer enneakis (glycylseryl) linker (451-468) -scFvlh anti-TNFRSF9 Homo sapiens (469-719), 11-scFv-v2 C120 (VL)-C49 (VH) [V-LAMBDA (Homo sapiens IGLV1-4702 (91.8%) -IGLJ201 (90.9%) VL G120>C (571), CDR-IMGT [8.3.11] (493-501.519-521.558-568)) (469-578) -20-mer tetrakis(tetraglycyl-seryl) linker (579-598) -VH (Homo sapiens IGHV3-2301 (93.9%) -IGHD -IGHJ401 (100%) VH G49>C (642), CDR-IMGT [8.8.14] (624-631.649-656.695-708)) (599-719)]]; (223-214')-disulfide with L-kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-3901 (86.3%) -IGKJ101 (100%), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (153'), V101 (191')) (108'-214')]; dimer (229-229'':232-232'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa

HER2-Positive Solid Tumor

Yuhan Corporationmonoclonal_antibodyPhase 1/2Active

CCC

48/ 100

Provisional rating · Methodology v0.2

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0 Active assets in the HER2-Positive Solid Tumor cohort.

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