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H-gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-23*01 (81.6%) -(IGHD) -IGHJ3*02 (91.7%) M123>T (114), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-218')-disulfide with L-kappa light chain humanized (1'-218') [VKAPPA (Homo sapiens IGKV1-33*01 (87.8%) -IGKJ4*01 (100%), CDR-IMGT [6.3.13] (27'-32'.50'-52'.89'-101')) (1'-111')-Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPAA45.1 (157'), V101 (195')) (112'-218')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

Clear Cell RCC

Genentech, Inc.monoclonal_antibodyPhase 1Active
CC
43/ 100
Provisional rating · Methodology v0.2

Rating breakdown

Clinical Evidence
28/ 100
Competitive Position
95/ 100

Competitive context

115 Active assets in the Clear Cell RCC cohort.

Asset / SponsorPhaseRating
gw786034
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Phase 4BBB
Girentuximab
Massachusetts General Hospital
Phase 3BB
gw786034
Academic and Community Cancer Research United
Phase 4BB
CLOSTRIDIUM BUTYRICUM MIYAIRI 588
City of Hope Medical Center
Phase 3BB
IMMUNOGLOBULIN G4, ANTI-(HUMAN PROGRAMMED CELL DEATH PROTEIN 1) (HUMAN MONOCLONAL REGN2810 HEAVY CHAIN), DISULFIDE WITH HUMAN MONOCLONAL REGN2810 .KAPPA.-CHAIN, DIMER
Regeneron Pharmaceuticals
Phase 2BB

View all 50 →

Same molecule, other indications

H-gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-23*01 (81.6%) -(IGHD) -IGHJ3*02 (91.7%) M123>T (114), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-218')-disulfide with L-kappa light chain humanized (1'-218') [VKAPPA (Homo sapiens IGKV1-33*01 (87.8%) -IGKJ4*01 (100%), CDR-IMGT [6.3.13] (27'-32'.50'-52'.89'-101')) (1'-111')-Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPAA45.1 (157'), V101 (195')) (112'-218')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa is also rated in:

Locally Advanced or Metastatic Solid TumorsDormant
CC
Indicative ·
41 / 100
View asset →
head and neck squamous cell carcinomaDormant
CC
Indicative ·
41 / 100
View asset →
triple-negative breast carcinomaDormant
CC
Indicative ·
41 / 100
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