human vascular endothelial growth factor receptor 1 (VEGFR-1) fragment 129-228 comprising the second extracellular domain of the VEGF receptor (VEGFR-D2), [N<sup>196</sup>>A<sup>68</sup>]-variant, anti-(human vascular endothelial growth factor (VEGF) (1-100 in the current sequence) fused, via a (G4S)3 peptide linker (101-115), to gamma 1 heavy chain (116-563) [VH (Homo sapiens IGHV3-23*04 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.9] (146-150.165-181.214-222)) (116-233) -Homo sapiens IGHG1*03 (CH1 (234-331), hinge (332-346), CH2 S<sup>414</sup>>A, E<sup>449</sup>>A, K<sup>450</sup>>A (347-456), CH3 (457-561), CHS (562-563)) (234-563)], (336-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 -IGKJ1*01, CDRKabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; dimer (342-342'', 345-345'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa
HCC
Rating breakdown
- Clinical Evidence
- 28/ 100
- Competitive Position
- 81/ 100
Competitive context
520 Active assets in the HCC cohort.
| Asset / Sponsor | Phase | Rating |
|---|---|---|
Adefovir Bukwang Pharmaceutical | Phase 4 | BBB |
Huaier Granule Tongji Hospital | Phase 4 | BBB |
Sorafenib Bayer | Phase 4 | BBB |
Carboplatin AstraZeneca | Phase 4 | BB |
Theprubicin RWTH Aachen University | Phase 4 | BB |
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Same molecule, other indications
human vascular endothelial growth factor receptor 1 (VEGFR-1) fragment 129-228 comprising the second extracellular domain of the VEGF receptor (VEGFR-D2), [N<sup>196</sup>>A<sup>68</sup>]-variant, anti-(human vascular endothelial growth factor (VEGF) (1-100 in the current sequence) fused, via a (G4S)3 peptide linker (101-115), to gamma 1 heavy chain (116-563) [VH (Homo sapiens IGHV3-23*04 -(IGHD) -IGHJ4*01, CDR-Kabat [5.17.9] (146-150.165-181.214-222)) (116-233) -Homo sapiens IGHG1*03 (CH1 (234-331), hinge (332-346), CH2 S<sup>414</sup>>A, E<sup>449</sup>>A, K<sup>450</sup>>A (347-456), CH3 (457-561), CHS (562-563)) (234-563)], (336-214')-disulfide with kappa light chain (1'-214') [V-KAPPA (Homo sapiens IGKV1-12*01 -IGKJ1*01, CDRKabat [11.7.9] (24'-34'.50'-56'.89'-97')) (1'-107') -Homo sapiens IGKC*01 (108'-214')]; dimer (342-342'', 345-345'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa is also rated in:
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