Pyruvate
Human Papillomavirus-Related Squamous Cell Carcinoma
Explore 17 assets in Human Papillomavirus-Related Squamous Cell Carcinoma →Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
Pamela Munster
Modality
Small molecule
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05472220CT.gov Alpelisib in Combination With Carboplatin in Patients With Solid Tumors and HPV-Positive Squamous Cell Carcinoma | — | Withdrawn | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Human Papillomavirus-Related Squamous Cell Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pyruvate (this asset) | Pamela Munster | P1 | CC · 43 |
| Cyclophosphamide | Christian Hinrichs | P2 | B |
| Fludarabine | Christian Hinrichs | P2 | B |
| e7 tcr-t cells | Christian Hinrichs | P2 | B |
| 9-valent human papillomavirus recombinant vaccine | Shanghai Bovax Biotechnology Co., Ltd. | P3 | B |
| Retifanlimab | Jennifer Dorth | P2 | CCC |
| scg142 | SCG Cell Therapy Pte. Ltd. | P1/2 | CCC |
| Regorafenib | Institut Bergonié | P1/2 | CC |
| Alpelisib | Pamela Munster | P1 | CC |
+10 more in the Human Papillomavirus-Related Squamous Cell Carcinoma cohort
Other indications for Pyruvate
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Prostate Cancer | — | P2 | B · 56 |
| Prostate Carcinoma | — | P2 | B · 56 |
| Relapsing-Remitting Multiple Sclerosis | — | P2 | CCC · 52 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pyruvate in Human Papillomavirus-Related Squamous Cell Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 13, 2026. Accessed July 13, 2026. https://terminal.floatz.ai/assets/pyruvate-human-papillomavirus-related-squamous-cell-carcinoma
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