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Immunoglobulin G1, anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal SHR-1805 ?1-chain), complex with human-Mus musculus monoclonal SHR-1805 ?-chain, dimer, thioether with N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[(1R)-1-cyclopropyl-2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3?,4?:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]glycinamide

Breast Cancer

Fudan Universityantibody_drug_conjugatePhase 4 / ApprovedActive
BB
67/ 100
Provisional rating · Methodology v0.2

Rating breakdown

Clinical Evidence
70/ 100
Competitive Position
59/ 100

Competitive context

848 Active assets in the Breast Cancer cohort.

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Same molecule, other indications

Immunoglobulin G1, anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal SHR-1805 ?1-chain), complex with human-Mus musculus monoclonal SHR-1805 ?-chain, dimer, thioether with N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[(1R)-1-cyclopropyl-2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3?,4?:6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]glycinamide is also rated in:

colorectal cancerActive
BB
Indicative · Phase 3
66 / 100
View asset →
non-small cell lung carcinomaActive
BB
Indicative · Phase 3
66 / 100
View asset →
HER2 positive breast carcinomaActive
BB
Indicative · Phase 4
64 / 100
View asset →

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