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immunoglobulin G1-kappa, anti-[Homo sapiens MSTN (myostatin, growth differentiation factor 8, GDF8, GDF-8) latent myostatin complex], humanized monoclonal antibody;

Spinal Muscular Atrophy (SMA)

Hoffmann-La Rochemonoclonal_antibodyPhase 2/3Active
B
57/ 100
Provisional rating · Methodology v0.2

Rating breakdown

Clinical Evidence
42/ 100
Competitive Position
89/ 100

Competitive context

21 Active assets in the Spinal Muscular Atrophy (SMA) cohort.

Asset / SponsorPhaseRating
Nusinersen
Scholar Rock, Inc.
Phase 4A
Risdiplam
Scholar Rock, Inc.
Phase 4A
NON-REPLICATING RECOMBINANT SELF-COMPLEMENTARY (SC) ADENO-ASSOCIATED VIRUS SEROTYPE 9 (AAV9) VECTOR CONTAINING THE CDNA OF THE SURVIVAL OF MOTOR NEURON 2 (SMN2) GENE UNDER THE CONTROL OF THE HYBRID CYTOMEGALOVIRUS (CMV) ENHANCER/CHICKEN BETA-ACTIN PROMOTER (CBA)
Novartis Pharmaceuticals
Phase 4A
oav101
Novartis Pharmaceuticals
Phase 4BBB
Srk-015
Scholar Rock, Inc.
Phase 3BB

View all 40 →

Same molecule, other indications

immunoglobulin G1-kappa, anti-[Homo sapiens MSTN (myostatin, growth differentiation factor 8, GDF8, GDF-8) latent myostatin complex], humanized monoclonal antibody; is also rated in:

Overweight With One Weight Related ComorbidityDormant
CCC
Indicative ·
53 / 100
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obesity disorderDormant
CCC
Indicative ·
52 / 100
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obesity disorderDormant
CCC
Indicative ·
50 / 100
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