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Immunoglobulin G4-kappa, anti-[Homo sapiens LGALS3 (galectin 3)], humanized monoclonal antibody (gamma4 heavy chain humanized (1-442) [VH (Homo sapiens IGHV1-3*01 (88.7%) -(IGHD) -IGHJ6*01 (93.3%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116)-Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10 (CH1 (117-214), hinge 1-12 S10>P (224)(215-226), CH2 L92 (305) (227-336), CH3 (337-441), CHS K2>del (442)) (117-442)], (130-219')-disulfide with kappa light chain humanized (1'-219') [V-KAPPA(Homo sapiens IGKV2D-29*02 (89.0%) -IGKJ2*01(100%), CDR-IMGT [11.3.9] (27-37.55-57.94-102)) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1(158), V101 (196) (113'-219')]; dimer (222-222'':225-225'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa)

Alzheimer Disease

TrueBinding, Inc.monoclonal_antibodyPhase 2Active
B
58/ 100
Provisional rating · Methodology v0.2

Rating breakdown

Clinical Evidence
53/ 100
Competitive Position
65/ 100

Competitive context

316 Active assets in the Alzheimer Disease cohort.

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Akiva Mintz
Phase 4BBB
Cipralex
NYU Langone Health
Phase 4BBB
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Carnot Laboratories
Phase 4BBB
FLORTAUCIPIR
Eli Radiopharma
Phase 4BBB
Sertraline
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Same molecule, other indications

Immunoglobulin G4-kappa, anti-[Homo sapiens LGALS3 (galectin 3)], humanized monoclonal antibody (gamma4 heavy chain humanized (1-442) [VH (Homo sapiens IGHV1-3*01 (88.7%) -(IGHD) -IGHJ6*01 (93.3%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116)-Homo sapiens IGHG4*01, nG4m(a) CH2 L92, G4v5 h P10 (CH1 (117-214), hinge 1-12 S10>P (224)(215-226), CH2 L92 (305) (227-336), CH3 (337-441), CHS K2>del (442)) (117-442)], (130-219')-disulfide with kappa light chain humanized (1'-219') [V-KAPPA(Homo sapiens IGKV2D-29*02 (89.0%) -IGKJ2*01(100%), CDR-IMGT [11.3.9] (27-37.55-57.94-102)) (1'-112') -Homo sapiens IGKC*01 (100%), Km3 A45.1(158), V101 (196) (113'-219')]; dimer (222-222'':225-225'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa) is also rated in:

Parkinson diseaseDormant
CCC
Indicative ·
53 / 100
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ischemic strokeDormant
CCC
Indicative ·
48 / 100
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