Irinotecan

Phase 1

M.D. Anderson Cancer CenterSmall moleculePhase 1Active

41/ 100

Provisional rating · Methodology v0.2

Rating breakdown

10 Active assets in the Phase 1 cohort.

Asset / Sponsor	Phase	Rating
Boditrectinib Handok Inc.	Phase 1	CC
Fludarabine M.D. Anderson Cancer Center	Phase 1	CC
allogeneic natural killer (NK) cells isolated from peripheral blood leukapheresis of individual donors. The cells are co-cultured in media containing interleukin 15 (IL-15) and nicotinamide (NAM, niacinamide) with expansion enhanced by the presence of feeder cells. The final cell population consists of 97-99% CD3-CD56+ NK cells, with >10% expressing CD16 (also known as Fc?RIII) and CD62L (also known as L-selectin) and with capacity to degranulate (surface expression of CD107? [Lysosome-associated membrane glycoprotein 1]; >10%), and to kill target cells (>10%) in co-culture assays against human cancer cell lines. M.D. Anderson Cancer Center	Phase 1	CC
sar445877 M.D. Anderson Cancer Center	Phase 1	CC
FLUOROURACILUM M.D. Anderson Cancer Center	Phase 1	CC