Isis-681257 (Galnac3--Conjugated Aso Targeting Human Lipoprotein (A) )
Hyperlipoproteinemia
Explore 1 assets in Hyperlipoproteinemia →Floatz Rating
D30/100
Confidence
Indicative
Sponsor
University Medical Centre Ljubljana
Modality
nucleic_acid
Development Phase
N/A
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
15Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04993664CT.gov Influence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA) | — | Withdrawn | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hyperlipoproteinemia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Isis-681257 (Galnac3--Conjugated Aso Targeting Human Lipoprotein (A) ) (this asset) | University Medical Centre Ljubljana | N/A | D · 30 |
| Laropiprant | Ludwig-Maximilians - University of Munich | P4 | B |
| Niacin | Ludwig-Maximilians - University of Munich | P4 | B |
| Evolocumab | University Medical Centre Ljubljana | N/A | D |
| Alirocumab | University Medical Centre Ljubljana | N/A | D |
Other indications for Isis-681257 (Galnac3--Conjugated Aso Targeting Human Lipoprotein (A) )
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Cardiovascular Disorder | — | P3 | B · 59 |
| Acute Coronary Syndrome | — | N/A | D · 30 |
| Inflammatory Disease | — | N/A | D · 30 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Isis-681257 (Galnac3--Conjugated Aso Targeting Human Lipoprotein (A) ) in Hyperlipoproteinemia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/isis-681257-galnac3-conjugated-aso-targeting-human-lipoprotein-a-hyperlipoproteinemia
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