Melphalan
Acute Leukemia Of Ambiguous Lineage
Explore 43 assets in Acute Leukemia Of Ambiguous Lineage →Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Masonic Cancer Center, University of Minnesota
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03674411CT.gov Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Acute Leukemia Of Ambiguous Lineage
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Melphalan (this asset) | Masonic Cancer Center, University of Minnesota | P2 | CCC · 53 |
| Cyclophosphamide | SWOG Cancer Research Network | P2 | BB |
| L-Ofloxacin | Children's Oncology Group | P3 | BB |
| Cytarabine | SWOG Cancer Research Network | P2 | B |
| Vincristine Sulfate | Children's Oncology Group | P2 | B |
| Fludarabine | Janssen Research & Development, LLC | P2 | B |
| Methotrexate | SWOG Cancer Research Network | P2 | B |
| Revumenib | SWOG Cancer Research Network | P2 | B |
| Dexasone | SWOG Cancer Research Network | P2 | B |
+42 more in the Acute Leukemia Of Ambiguous Lineage cohort
Other indications for Melphalan
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Diffuse Large B-Cell Lymphoma | — | P4 | BBB · 76 |
| Myelodysplastic/Myeloproliferative Neoplasm | — | P2/3 | BBB · 76 |
| Cancer Of Unknown Primary Site | — | P2/3 | BBB · 72 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Melphalan in Acute Leukemia Of Ambiguous Lineage. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/melphalan-acute-leukemia-of-ambiguous-lineage
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