Melphalan
Acute Myeloid Leukemia By FAB Classification
Explore 16 assets in Acute Myeloid Leukemia By FAB Classification →Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
City of Hope Medical Center
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07582172CT.gov Total Marrow and Lymphoid Irradiation in Combination With Fludarabine and Melphalan as Conditioning for Allogeneic Peripheral Blood Stem Cell Hematopoietic Cell Transplant in Older Patients With Refractory and Relapsed Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome | — | Not Yet Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Acute Myeloid Leukemia By FAB Classification
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Melphalan (this asset) | City of Hope Medical Center | P2 | CCC · 53 |
| Daunomycin | Wake Forest University Health Sciences | P3 | BBB |
| Idarubicin | University of Nebraska | P3 | BB |
| 2 (1H))-QUINOLINONE,6-(AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-4-(3-CHLOROPHENYL)-1-METHYL-,(+)- | National Cancer Institute (NCI) | P3 | BB |
| Valspodar | National Cancer Institute (NCI) | P3 | BB |
| Mercaptopurine Anhydrous | Roswell Park Cancer Institute | P3 | BB |
| Azacitidine | guomei | P2 | BB |
| Caspofungin | Children's Oncology Group | P3 | BB |
| Fluconazole | Children's Oncology Group | P3 | BB |
+41 more in the Acute Myeloid Leukemia By FAB Classification cohort
Other indications for Melphalan
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Diffuse Large B-Cell Lymphoma | — | P4 | BBB · 76 |
| Myelodysplastic/Myeloproliferative Neoplasm | — | P2/3 | BBB · 76 |
| Cancer Of Unknown Primary Site | — | P2/3 | BBB · 72 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- DaunomycinWake Forest University Health SciencesBBB
- IdarubicinUniversity of NebraskaBB
- 2 (1H))-QUINOLINONE,6-(AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-4-(3-CHLOROPHENYL)-1-METHYL-,(+)-National Cancer Institute (NCI)BB
- ValspodarNational Cancer Institute (NCI)BB
- Mercaptopurine AnhydrousRoswell Park Cancer InstituteBB
Citation
Floatz Terminal. Melphalan in Acute Myeloid Leukemia By FAB Classification. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/melphalan-acute-myeloid-leukemia-by-fab-classification
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