Floatz Rating
B57/100
Confidence
Indicative
Sponsor
National Center for Research Resources (NCRR)
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT00004758CT.gov Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Infantile Spasms
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Neurotop (this asset) | National Center for Research Resources (NCRR) | P2 | B · 57 |
| Prednisolone | University of California, Los Angeles | P4 | BBB |
| Corticotropin | All India Institute of Medical Sciences | P4 | BBB |
| Pyridoxol | Lady Hardinge Medical College | P3 | BB |
| Benzeneethanamine, N-Ethyl-?-Methyl-4-(Trifluoromethyl)-, Hydrochloride, (±)- | Children's Hospital of Orange County | P3 | BB |
| Vigabatrin | Amzell | P4 | BB |
| gwp42003-p | Jazz Pharmaceuticals | P3 | BB |
| Tetracosactide | University of Colorado, Denver | P3 | B |
| amz002 injectable , 0./ml | Amzell | P3 | B |
+10 more in the Infantile Spasms cohort
Other indications for Neurotop
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Epilepsy | — | P4 | BBB · 74 |
| Focal Epilepsy | — | P4 | BBB · 74 |
| Bipolar Disorder | — | P4 | BBB · 72 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Neurotop in Infantile Spasms. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/neurotop-infantile-spasms
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