Pvsripo (Chimeric Poliovirus (Pv), Consisting Of The Type-1 Sabin Vaccine Strain Carrying A Foreign Internal Ribosome Entry Site (Ires) From Human Rhinovirus Type-2) (Hrv2)
Melanoma
Explore 435 assets in Melanoma →Floatz Rating
CCC50/100
Confidence
Indicative
Sponsor
Istari Oncology, Inc.
Modality
other_biological
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
41High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04577807CT.gov LUMINOS-102: Lerapolturev With or Without Immune Checkpoint Blockade in Advanced PD-1 Refractory Melanoma | — | Completed | — | — | — |
NCT04125719CT.gov PVSRIPO in Combination With Nivolumab in Melanoma | — | Withdrawn | — | — | — |
NCT03712358CT.gov PVSRIPO for Patients With Unresectable Melanoma | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Melanoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Pvsripo (Chimeric Poliovirus (Pv), Consisting Of The Type-1 Sabin Vaccine Strain Carrying A Foreign Internal Ribosome Entry Site (Ires) From Human Rhinovirus Type-2) (Hrv2) (this asset) | Istari Oncology, Inc. | P2 | CCC · 50 |
| Gm-Csf | Ultimovacs ASA | P4 | BBB |
| Sargramostim | Mayo Clinic | P3 | BBB |
| Cediranib | M.D. Anderson Cancer Center | P3 | BBB |
| Ifa | Craig L Slingluff, Jr | P2 | BB |
| Cyclophosphamide | Primmune Therapeutics, Inc. | P4 | BB |
| Temsirolimus | University of Regensburg | P2 | BB |
| Tebentafusp | Immunocore Ltd | P3 | BB |
| Dacarbazine | Suzhou BlueHorse Therapeutics Co., Ltd. | P3 | BB |
+42 more in the Melanoma cohort
Other indications for Pvsripo (Chimeric Poliovirus (Pv), Consisting Of The Type-1 Sabin Vaccine Strain Carrying A Foreign Internal Ribosome Entry Site (Ires) From Human Rhinovirus Type-2) (Hrv2)
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Malignant Glioma | — | P2 | B · 58 |
| Brain Neoplasm | — | P2 | CCC · 52 |
| Glioblastoma | — | P2 | CCC · 50 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Pvsripo (Chimeric Poliovirus (Pv), Consisting Of The Type-1 Sabin Vaccine Strain Carrying A Foreign Internal Ribosome Entry Site (Ires) From Human Rhinovirus Type-2) (Hrv2) in Melanoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/pvsripo-chimeric-poliovirus-pv-consisting-of-the-type-1-sabin-vaccine-strain-carrying-a-foreign-internal-ribosome-entry-site-ires-from-human-rhinovirus-type-2-hrv2-melanoma
Are you the sponsor?
Submit your data room for a Verified Rating. The public-data rating remains visible alongside.
Contact →