Sirexatamab
Metastatic Malignant Neoplasm In The Colon
Floatz Rating
CCC51/100
Confidence
Indicative
Sponsor
Leap Therapeutics, Inc.
Modality
monoclonal_antibody
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05480306CT.gov Phase 2 Study of DKN-01 in Colorectal Cancer | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Metastatic Malignant Neoplasm In The Colon
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Sirexatamab (this asset) | Leap Therapeutics, Inc. | P2 | CCC · 51 |
| Binimetinib | Pierre Fabre Medicament | P3 | BB |
| Irinotecan | Oncolytics Biotech | P4 | BB |
| Aflibercept | Sanofi | P3 | BB |
| Adriamycin | Northwell Health | P4 | B |
| Immunoglobulin G2, Anti-(Human Ctla-4 (Antigen)) (Human Monoclonal Cp-675206 Clone 11.2.1 Heavy Chain) Disulphide With Human Monoclonal Cp-675206 Clone 11.2.1 Light Chain, Dimer | Centre Georges Francois Leclerc | P2 | B |
| Durvalumab | University of Iowa | P2 | B |
| Famitinib | Jiangsu HengRui Medicine Co., Ltd. | P3 | B |
| Vemurafenib | Fudan University | P3 | B |
+42 more in the Metastatic Malignant Neoplasm In The Colon cohort
Other indications for Sirexatamab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Uterine Cancer | — | P2 | B · 57 |
| Carcinosarcoma | — | P2 | B · 57 |
| Colorectal Adenocarcinoma | — | P2 | CCC · 54 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Citation
Floatz Terminal. Sirexatamab in Metastatic Malignant Neoplasm In The Colon. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 13, 2026. https://terminal.floatz.ai/assets/sirexatamab-metastatic-malignant-neoplasm-in-the-colon
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