Floatz Rating
B57/100
Confidence
Indicative
Sponsor
UNC Lineberger Comprehensive Cancer Center
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03907657CT.gov Contrast-enhanced Ultrasound as a Screening Tool for Kidney Cancer in Patients With Von-Hippel Lindau | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Indicative
Detailed axis rationale is planned and will be published soon.
Same indication · Von Hippel-Lindau Disease
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Sulfur Hexafluoride (this asset) | UNC Lineberger Comprehensive Cancer Center | P2 | B · 57 |
| Belzutifan | Merck Sharp & Dohme LLC | P3 | BB |
| Palbociclib | Merck Sharp & Dohme LLC | P3 | B |
| Lenvatinib | Merck Sharp & Dohme LLC | P3 | B |
| Cabozantinib | Merck Sharp & Dohme LLC | P3 | B |
| Everolimus | Merck Sharp & Dohme LLC | P3 | B |
| Nivolumab | Merck Sharp & Dohme LLC | P3 | B |
| 17 allylamino-17-demethoxygeldanamycin | National Cancer Institute (NCI) | P2 | B |
| Rvp-001 | Reveal Pharmaceuticals Inc. | P2 | B |
+8 more in the Von Hippel-Lindau Disease cohort
Other indications for Sulfur Hexafluoride
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Renal Cell Carcinoma | — | P4 | BB · 67 |
| Stroke Disorder | — | P2 | B · 62 |
| Carotid Stenosis | — | P3 | B · 62 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Sulfur Hexafluoride in Von Hippel-Lindau Disease. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/sulfur-hexafluoride-von-hippel-lindau-disease
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