Floatz Rating
CC41/100
Confidence
Indicative
Sponsor
Milton S. Hershey Medical Center
Modality
protein_peptide
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
35Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06482853CT.gov Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension | — | Recruiting | — | — | — |
NCT03777215CT.gov Angiotensin-(1-7) and Energy Expenditure in Human Obesity | — | Active Not Recruiting | — | — | — |
NCT03604289CT.gov Angiotensin 1-7 in Obesity Hypertension | — | Terminated | — | — | — |
NCT02646475CT.gov Metabolic Effects of Angiotensin-(1-7) | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
59High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Obesity Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Talfirastide (this asset) | Milton S. Hershey Medical Center | P1 | CC · 41 |
| Phentermine | Russell McCulloh, MD | P4 | BBB |
| vi-0521 | VIVUS LLC | P4 | BBB |
| Tirzepatide | Royal North Shore Hospital | P4 | BBB |
| Sibutramine | Falquetomed | P4 | BBB |
| Cagrilintide | Novo Nordisk A/S | P3 | BBB |
| Survodutide | Boehringer Ingelheim | P3 | BBB |
| Mazdutide | China National Center for Cardiovascular Diseases | P4 | BBB |
| Exenatide | Vivani Medical, Inc | P4 | BBB |
+42 more in the Obesity Disorder cohort
Other indications for Talfirastide
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Hodgkins Lymphoma | — | P2 | CCC · 54 |
| Lymphopenia | — | P2 | CCC · 54 |
| Bone Cancer | — | P2 | CCC · 54 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Talfirastide in Obesity Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/talfirastide-obesity-disorder
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