Trametinib
Grade III Glioma
Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03919071CT.gov Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Grade III Glioma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Trametinib (this asset) | National Cancer Institute (NCI) | P2 | CCC · 53 |
| Sorafenib | Virginia Commonwealth University | P2 | BB |
| Everolimus | Nationwide Children's Hospital | P2 | B |
| Perampanel | Mayo Clinic | P4 | B |
| Thioguanine Anhydrous | M.D. Anderson Cancer Center | P2 | B |
| Capecitabine | M.D. Anderson Cancer Center | P2 | B |
| Pamiparib | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | P1/2 | B |
| Valproic Acid | Virginia Commonwealth University | P2 | B |
| FET | Thomas Hope | P2 | B |
+29 more in the Grade III Glioma cohort
Other indications for Trametinib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Melanoma | — | P4 | BB · 69 |
| Anaplastic Pleomorphic Xanthoastrocytoma | — | P4 | BB · 69 |
| Anaplastic Oligodendroglioma | — | P4 | BB · 69 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Citation
Floatz Terminal. Trametinib in Grade III Glioma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 13, 2026. https://terminal.floatz.ai/assets/trametinib-grade-iii-glioma
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