1 asset in Extramedullary Plasmacytoma

Autologous Peripheral Blood Mononuclear Cell (Pbmc)-Derived T Lymphocytes Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector Encodinga Chimeric Antigen Receptor (Car) Targeting Two Epitopes Of The Human B Cell Maturation Antigen (Bcma) Under The Control Of A Human Elongation Factor 1 Alpha (Ef1.Alpha.) Promoter The Coding Sequence Comprises A Human Cd8 Alpha Signal Peptide (Cd8.Alpha. Sp), A Bcma Targeting Domain Consisting Of Two Variable Heavy Chain-Only Antibodies (Vhh1 And Vhh2) Targeting Two Distinct Bcma Epitopes, A Human Cd8 Alpha Hinge And Transmembrane Domain (Cd8.Alpha. Hinge + Tm), A Human Cd137 Cytoplasmic Domain (4-1Bb) And A Human Cd3 Zeta Cytoplasmic Domain (Cd3.Zeta.). The Vector Genome Contains A Chimeric Rous Sarcoma Virus (Rsv)/Truncated 5'Ltr And A Self-Inactivating 3'Ltr-Sin (.Delta.-U3)