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H-gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-23*01 (81.6%) -(IGHD) -IGHJ3*02 (91.7%) M123>T (114), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-218')-disulfide with L-kappa light chain humanized (1'-218') [VKAPPA (Homo sapiens IGKV1-33*01 (87.8%) -IGKJ4*01 (100%), CDR-IMGT [6.3.13] (27'-32'.50'-52'.89'-101')) (1'-111')-Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPAA45.1 (157'), V101 (195')) (112'-218')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa

NSCLC

Genentech, Inc.monoclonal_antibodyPhase 1Active
C
37/ 100
Provisional rating · Methodology v0.2

Rating breakdown

Clinical Evidence
28/ 100
Competitive Position
65/ 100

Competitive context

1205 Active assets in the NSCLC cohort.

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Jonsson Comprehensive Cancer Center
Phase 3BBB
Zorifertinib
Alpha Biopharma (Jiangsu) Co., Ltd.
Phase 2/3BBB
Glumetinib
Shanghai JMT-Bio Inc.
Phase 3BBB
d-0316
Betta Pharmaceuticals Co., Ltd.
Phase 2/3BBB
Onartuzumab
Hoffmann-La Roche
Phase 3BBB

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Same molecule, other indications

H-gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-23*01 (81.6%) -(IGHD) -IGHJ3*02 (91.7%) M123>T (114), CDR-IMGT [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (216) (120-217), hinge 1-15 (218-232), CH2 (233-342), CH3 E12 (358), M14 (360) (343-447), CHS (448-449)) (120-449)], (222-218')-disulfide with L-kappa light chain humanized (1'-218') [VKAPPA (Homo sapiens IGKV1-33*01 (87.8%) -IGKJ4*01 (100%), CDR-IMGT [6.3.13] (27'-32'.50'-52'.89'-101')) (1'-111')-Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPAA45.1 (157'), V101 (195')) (112'-218')]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa is also rated in:

nonpapillary renal cell carcinomaDormant
CC
Indicative ·
43 / 100
View asset →
Locally Advanced or Metastatic Solid TumorsDormant
CC
Indicative ·
41 / 100
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head and neck squamous cell carcinomaDormant
CC
Indicative ·
41 / 100
View asset →

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