Umitrelimorgene Autodencel Human Lysosomal Associated Membrane Protein 1/Human Cytomegalovirus (Hcmv) 65 Kda Matrix Protein Mrna
Adult Glioblastoma
Explore 23 assets in Adult Glioblastoma →Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
University of Florida
Modality
gene_therapy
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04573140CT.gov A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM) | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Adult Glioblastoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Umitrelimorgene Autodencel Human Lysosomal Associated Membrane Protein 1/Human Cytomegalovirus (Hcmv) 65 Kda Matrix Protein Mrna (this asset) | University of Florida | P1 | CC · 43 |
| Temsirolimus | University Hospital Heidelberg | P2 | BBB |
| Cediranib | Lawrence Recht | P2 | BBB |
| 2 (1H))-QUINOLINONE,6-(AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL)-4-(3-CHLOROPHENYL)-1-METHYL-,(+)- | National Cancer Institute (NCI) | P2 | BB |
| Irinotecan | NaviFUS Corporation | P3 | BB |
| Vorinostat | National Cancer Institute (NCI) | P2 | BB |
| Gefitinib | National Cancer Institute (NCI) | P2 | BB |
| Sorafenib | National Cancer Institute (NCI) | P2 | BB |
| Vismodegib | University Hospital Heidelberg | P2 | BB |
+42 more in the Adult Glioblastoma cohort
Other indications for Umitrelimorgene Autodencel Human Lysosomal Associated Membrane Protein 1/Human Cytomegalovirus (Hcmv) 65 Kda Matrix Protein Mrna
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Medulloblastoma | — | P1 | CC · 43 |
| Malignant Glioma | — | P1 | CC · 41 |
| Glioblastoma | — | P1 | C · 37 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Umitrelimorgene Autodencel Human Lysosomal Associated Membrane Protein 1/Human Cytomegalovirus (Hcmv) 65 Kda Matrix Protein Mrna in Adult Glioblastoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/umitrelimorgene-autodencel-human-lysosomal-associated-membrane-protein-1human-cytomegalovirus-hcmv-65-kda-matrix-protein-mrna-adult-glioblastoma
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