Umitrelimorgene Autodencel Human Lysosomal Associated Membrane Protein 1/Human Cytomegalovirus (Hcmv) 65 Kda Matrix Protein Mrna
Glioblastoma
Explore 342 assets in Glioblastoma →Floatz Rating
C37/100
Confidence
Indicative
Sponsor
University of Florida
Modality
gene_therapy
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06389591CT.gov RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM) | — | Recruiting | — | — | — |
NCT04963413CT.gov RENEW: Feasibility of CMV RNA-Pulsed Dendritic Cells Vaccines for the Treatment of Newly Diagnosed Glioblastoma Patients. | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Glioblastoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Umitrelimorgene Autodencel Human Lysosomal Associated Membrane Protein 1/Human Cytomegalovirus (Hcmv) 65 Kda Matrix Protein Mrna (this asset) | University of Florida | P1 | C · 37 |
| Depatuxizumab Mafodotin | AbbVie | P3 | BB |
| Cintredekin Besudotox | INSYS Therapeutics Inc | P3 | BB |
| Camustine | Leland Metheny | P3 | BB |
| (+)-Vincristine | University of Cincinnati | P3 | BB |
| Irinotecan | University of Cincinnati | P3 | BB |
| Capecitabine | Northwell Health | P2 | BB |
| Lomustine | Telix Pharmaceuticals (Innovations) Pty Limited | P3 | BB |
| Carboplatin | Sichuan Honghe Biotechnology Co., Ltd. | P3 | BB |
+42 more in the Glioblastoma cohort
Other indications for Umitrelimorgene Autodencel Human Lysosomal Associated Membrane Protein 1/Human Cytomegalovirus (Hcmv) 65 Kda Matrix Protein Mrna
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Medulloblastoma | — | P1 | CC · 43 |
| Adult Glioblastoma | — | P1 | CC · 43 |
| Malignant Glioma | — | P1 | CC · 41 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Umitrelimorgene Autodencel Human Lysosomal Associated Membrane Protein 1/Human Cytomegalovirus (Hcmv) 65 Kda Matrix Protein Mrna in Glioblastoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/umitrelimorgene-autodencel-human-lysosomal-associated-membrane-protein-1human-cytomegalovirus-hcmv-65-kda-matrix-protein-mrna-glioblastoma
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